Within his second season he took his first Grand Prix victory at Rio de Janeiro in Brazil, where his impressive "about the outside" overtaking manoeuvre on Casey Stoner and Dani Pedrosa won him the nickname "Por Fuera". In 2004 he sealed an additional three triumphs, prior to the rise towards 250cc category annually later and taking four poles and six podiums in their maiden season. 2006 would have been to really do the coming-of-age year with the Mallorcan, who switched to Aprilia machinery and immediately took over as the favourite for your World Championship. He justified the hype with the impressive eight victories, equalling the pole position record at the same time with ten, and lifting the title within the emotional final race of the year at Valencia.
Another dominant year in 2007 saw Lorenzo retaining the quarter-litre title, wonderful nine of his victories via pole. At only twenty years old, he would have been a two-time 250cc World Champion and took on his biggest challenge as of yet by signing with the Yamaha factory team in MotoGP alongside Valentino Rossi. Lorenzo made a sudden impact from the premier class that has a stunning first five races. He took pole on his debut - becoming the initial man to do so since Max Biaggi ten years previously - and finished second in the astounding performance in Qatar. He accompanied the feat with pole on the next two races, becoming the 1st rider to search ‘three from three’ as part of his rookie season and turning both top spots into podium finishes.